# of Displayed Technologies: 10 / 20


Long-Term and At-Home Halo Gravity Traction
TS-003679 — The IP is an innovative approach to the preoperative treatment of severe spinal deformities, particularly in medically complex children. Traditionally, halo gravity traction (HGT) has been employed as a preoperative tool, involving hospital admission for the duration of treatment. However, for certain patients, especially those who are too young or medically complex, spinal surgery with instrumentation presents significant risks and challenges. The program offers two innovative pathways: Long-Term HGT: For patients deemed unsuitable candidates for immediate surgery due to medical complexity or unique deformities, a long-term halo gravity traction pathway is proposed. This involves applying the halo, utilizing gravity traction, and postponing definitive surgery to a later date, which would allow for optimization of spinal flexibility. Patients undergo a temporary hospital stay followed by discharge to home with the halo device (with the possibility of surgery considered at a later stage). At-Home HGT: Targeting a different subgroup of patients who are medically fit for spinal instrumentation surgery, the at-home HGT program enables patients to receive halo traction treatment at home instead of an extended hospital stay. After a short-term hospitalization, patients spend the remainder of their treatment period at home with the halo device. This allows for a more comfortable and cost-effective alternative to prolonged hospitalization. Currently in the conceptual stage, the program holds significant potential for transforming the treatment landscape for severe spinal deformities, providing safer, more patient-centric alternatives to traditional approaches.
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  • Inventors: Kadado, Allen; Miller, Kelly; Seilhamer, Crystal
  • Licensing Officer: Zalucha, Ellen

Noninvasive Gravity Traction
TS-003678 — The IP is a novel approach to the preoperative treatment of severe spinal deformities, particularly in younger patients. Traditionally, halo gravity traction involves the application of a halo device, which requires hospital admission and fixation in the cranium. However, some patients, namely children, may face challenges with anesthesia or have families who prefer noninvasive treatment options. The IP offers a solution by enabling families to apply traction therapy at home without the need for cranial fixation. The device comprises a torso vest with shoulder straps and an optional head support attachment for children without head control. By securing the patient to a frame, gravity traction is applied to the torso, effectively addressing spinal deformities. Its noninvasive nature eliminates the risks associated with anesthesia and cranial fixation, and it offers the flexibility of home-based treatment, reducing the need for hospitalization and improving patient comfort.
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  • Inventors: Kadado, Allen; Fedor, Jessica
  • Licensing Officer: Zalucha, Ellen

CPO-2 (continuous pulse oximeter) and Play on O-2 and C-3PO
TS-003440 — The Continuous Pulse Oximeter (CPO-2) is a conceptual wearable device designed for infants with Bronchopulmonary Dysplasia (BPD) and other patient populations requiring continuous oxygen monitoring. The National Institutes of Health estimates that 10,000-15,000 babies born in the United States develop BPD each year. Inspired by the concept of continuous glucose monitors (CGMs), the CPO-2 aims to offer a wireless, adhesive solution to address the challenges associated with traditional pulse oximeters. The intellectual property involves creating a device that is capable of reading oxygen saturations (spO2) without the need for a separate machine. Unlike current pulse oximeters that are minimally adhesive and connected to a machine via a cord, the CPO-2 would transmit information directly to a smartphone, eliminating the machine and cord, thereby reducing the risk of strangulation and skin breakdown issues. The adhesive component is expected to last for an extended period, potentially 7-10 days or more, reducing the need for frequent probe replacements. Potential applications include adoption by home care companies, which could provide the CPO-2 to families taking infants or children home on oxygen. The device could find utility across various age groups, offering a less cumbersome method for continuous oxygen saturation monitoring. RINCH has filed a provisional application (63/533,946) and the inventor continues to develop and refine this technology.
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  • Inventors: Ingram, Mindy
  • Licensing Officer: Zalucha, Ellen

Predictive Model of Sudden Cardiac Death in Anomalous Aortic Origin of Coronary Artery (AAOCA)
TS-003439 — The Predictive Model of Sudden Cardiac Death in Anomalous Aortic Origin of Coronary Artery (AAOCA) is a patient-specific computational modeling approach to predict ischemia risk in individuals with anomalous coronaries. Anomalous coronaries are variations or abnormalities in the anatomy of the coronary arteries. These anomalies can differ in presentation and severity, with some increasing the risk of heart problems, such as myocardial ischemia (reduced blood flow to the heart muscle), arrhythmias or sudden cardiac arrest. According to The Cleveland Clinic, up to 1% of the population has an anomalous coronary artery, and most cases are not dangerous. This predictive model utilizes morphological risk factors derived from advanced imaging data to offer a validated method for risk stratification, determining the need for surgery, selecting the type of surgery, assessing the effectiveness of surgery, and evaluating residual ischemia post-surgery. Because there are no effective risk stratification approaches for AAOCA individuals, predicting these life-threatening events is challenging. AAOCA is a significant cause of sudden death in children, and current understanding of the mechanisms leading to ischemia and sudden cardiac death (SCD) is limited. According to the Nora Eccles Harrison Cardiovascular Research and Training Institute, "SCD is one of the most significant causes of natural deaths globally. Annually, just over 300,000 US adult deaths are a result of sudden cardiac death. Roughly half of all cardiovascular disease deaths are from SCD." The proposed model addresses these gaps, potentially shifting the AAOCA field from uncertainty to clinical solutions. RINCH has filed a provisional application (63/502,524) for this technology. The inventors are planning additional refinement of the methodology and a clinical trial to validate the model in a prospective patient population. This technology is jointly owned with Georgia Institute of Technology.
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  • Inventors: Krishnamurthy, Rajesh
  • Licensing Officer: Zalucha, Ellen

Parent-Implemented Oral Nutrition, Eating and Esophageal Regulation (PIONEER) Products
TS-003438 — The Parent-Implemented Oral Nutrition, Eating and Esophageal Regulation (PIONEER) Products enhance development of oral-pharyngeal-esophageal motility in infants. This technology is a novel approach for training muscles in non-verbal patients, including neonates, infants, and individuals who have lost skills due to stroke, trauma, or developmental neuropathology. Unlike existing methods, these products stimulate muscles involved in esophageal peristalsis and airway protection without electrical stimulation. By engaging and pre-conditioning select muscles and nerves, the approach helps prevent developmental delays, cerebral palsy, and chronic eating and swallowing difficulties. Approximately half a million infants are admitted to NICUs in the USA annually, thus, the technology’s impact on infant feeding and airway issues could be significant. Potential applications range from diagnostic and therapeutic purposes to rehabilitative therapy for chronic tube-fed infants in Neonatal Intensive Care Units (NICUs) and post-discharge. RINCH has filed a patent application (PCT/US23/81696) and the inventor is continuing to conduct clinical investigations.
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  • Inventors: Jadcherla, Sudarshan
  • Licensing Officer: Zalucha, Ellen

VSV-based SARS-CoV-2 Vaccine Candidates and IgY Antibody as Prophylactic and Therapeutic Agents Against SARS-CoV-2 and Variants of Concern
TS-003437 — According to the CDC, roughly 1.1 million COVID-19 cases have been reported in the past year, and 81.4% of the U.S. population have received the updated booster dose. This therapeutic agent utilizes the vesicular stomatitis virus (VSV) vector to protect against SARS-CoV-2 and its variants. This innovative approach resulted in heightened immunogenicity of the vaccines compared to currently available options. Specifically, the utilization of the prefusion Spike protein, stabilized with six prolines (preS-6P), component in the vaccine formulation demonstrates superior efficacy in eliciting a robust immune response. Two distinguishing features of this vaccine platform are the proposed intranasal administration and the live attenuated virus design, both of which induce robust mucosal immunity. In addition to the vaccine platform, the inventors used the platform to develop specific IgY antibodies to SARS-CoV-2 that might be used as a prophylactic, therapeutic or diagnostic antibody. This technology holds significant promise in the development of effective vaccines to combat SARS-CoV-2 and its variants long-term. RINCH has filed a provisional application (63/452,870) and the inventors continue to evaluate the efficacy of the vaccine candidates in animal models. This technology is jointly owned with The Ohio State University.
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  • Inventors: Peeples, Mark; KC, Mahesh
  • Licensing Officer: Zalucha, Ellen

Internal Hip Distraction
TS-002958 — Hip distraction, or arthrodiastasis, is a surgical option for end-stage diseases of the hip, such as Legg Calve Perthes disease, avascular necrosis, and end-stage osteoarthritis. The procedure improves mobility, decreases pain, and prevents further wear to avoid a total hip arthroplasty. However, the standard of care procedure requires an external device that uses large pins that are kept for 3-4 months which can be distressing for pediatric patients. NCH inventors have developed a completely internal hip-spanning device that allows for distraction and articulated hip motion. This device will likely reduce the problems associated with an external device such as infection, procedure failure, and psychosocial concerns.
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  • Inventors: Kadado, Allen
  • Licensing Officer: Zalucha, Ellen

Scoliosis 3D Model for Surgical Simulation
TS-002957 — Available 3D spine models do not optimize properties to simulate real-life bones, ligaments, tendons, viscoelasticity, or resistance that is present in a patient. Spine models are used by both surgeons and researchers for surgical planning, simulation, training, research and medical device development. By optimizing 3D printing materials, NCH inventors can produce patient-specific spine models that replicate the viscoelastic properties of the spine for a more accurate rendition. In addition to precise surgical planning, another benefit of utilizing viscoelastic accurate models is further medical device innovation to optimize surgical outcomes.
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  • Inventors: Kadado, Allen; Parthasarathy, Jayanthi
  • Licensing Officer: Zalucha, Ellen

Suicide Prevention App and Plug-in
TS-002725 — Globally, suicide is the second leading cause of death for individuals aged 15 to 24 years old. Researchers at Nationwide Children’s Hospital created an application and plug-in extension as a tool to potentially decrease youth suicide rates. The app has parental controls and monitoring features that notifies parents when their child is browsing suicidal content and blocks it to provide resources instead. High risk adolescents will be better protected and connected to their selected contacts, a therapist, school counselor, and suicide prevention hotline.
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  • Inventors: Farah, Ebyan; Bridge, Jeff; Rife, Franky; Ruch, Donna
  • Licensing Officer: Zalucha, Ellen

Orthosis Compliance Monitoring System
TS-002701 — Current devices for orthoses patients are limited by preventing providers from accessing patient brace compliance over time data. Researchers at Nationwide Children’s created the Orthosis Compliance Monitoring System to improve patient outcomes. The new cloud-based software automatically uploads wear data to the cloud every night, tracks brace compliance between clinic visits, and enables providers to send reminders and encouragements to patients.
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  • Inventors: Kadado, Allen; Pilotte, Holly; Richard, Heather; Tulchin-Francis, Kirsten
  • Licensing Officer: Zalucha, Ellen

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