TS-004524 — In engineered cardiovascular tissues, inhibiting purinergic signaling will promote high-quality neo tissue formation and prevent pathological remodeling. Inhibiting the P2Y12 receptor sustains a multitude of other necessary functions but prevents a detrimental excess.

TS-001227 — A team of physicians at Nationwide Children's Hospital have developed a process to improve the acceptance of implanted vascular grafts. This Tissue Engineered Vascular Graft (TEVG) is patient-specific. It seeds patient cells onto a biodegradable tubilar scaffold, which is designed to dissolve with hydrolysis so that only the growing vessel remains. This system, the Closed Seeding System, combines patient imaging data, 3D-printing capabilities, and efficient collection and subsequent seeding of patient cells onto the TEVG scaffolding.

TS-000620 — Physicians at Nationwide Children’s Hospital have developed a Tissue Engineered Vascular Graft (TEVG) by seeding patient cells onto a biodegradable tubular scaffold. The scaffold degrades by hydrolysis, ultimately leaving only the growing vessel in the patients. The Closed Seeding System enables efficient collection and seeding of patient cells onto the TEVG scaffold, which has been further optimized by using patient imaging data and 3D-printing capabilities to create patient-specific vascular grafts for implantation.

TS-000619 — Physicians at Nationwide Children’s Hospital have developed a Tissue Engineered Vascular Graft (TEVG) by seeding patient cells onto a biodegradable tubular scaffold. The scaffold degrades by hydrolysis, ultimately leaving only the growing vessel in the patients. The Closed Seeding System enables efficient collection and seeding of patient cells onto the TEVG scaffold, which has been further optimized by using patient imaging data and 3D-printing capabilities to create patient-specific vascular grafts for implantation. This is an improvement on an existing product. This second-generation system possesses all of the advantages of the previous system including improved safety, efficacy and simplicity. In addition, it has the potential for further improved efficacy and better efficiency. Benefits: Using current methods, few hospitals can perform implantations of tissue engineered vascular grafts. TEVG preparation requires advanced collection methods for the cells to be seeded onto the scaffold of the TEVG and must be performed in a sterile environment. The Closed Seeding System enables surgeons to collect patient cells and prepare the TEVG in a standard surgical setting, greatly expanding the availability of this surgery. Further Details/Stage of Development: The Closed Seeding System has been tested in an animal model of TEVG implantation. Potential Applications/Markets: Initial application of the technology would be used to seed a biodegradable tubular scaffold with autologous bone marrow derived mononuclear cells while simultaneously re-transfusing the residual bone marrow cells (primarily red blood cells) back to the patient. This technology could be used in any application where a specific component of a patient’s blood or bone marrow is removed and processed and the residual cells are returned to the donor. Opportunity/Seeking: Development Partner Commercial Partner Licensing IP Status: Patent Pending

TS-000244 — Researchers at Nationwide Children’s Hospital have developed a novel method for increasing the patency of biodegradable, synthetic vascular grafts. Administration or controlled release of one or more cytokines or chemokines was found to promote outward tissue remodeling of the vascular grafts and vascular neotissue formation. As a result, this method does not require cell seeding of the vascular graft, eliminating many problems associated with cell seeding such as contamination, loss of clinical utility due to added time for cell expansion, and difficulty in obtaining healthy autologous cells from diseased donors.

TS-000243 — Researchers at Nationwide Children’s Hospital have developed a novel method for increasing the patency of biodegradable, synthetic vascular grafts. Administration or controlled release of one or more cytokines or chemokines was found to promote outward tissue remodeling of the vascular grafts and vascular neotissue formation. As a result, this method does not require cell seeding of the vascular graft, eliminating many problems associated with cell seeding such as contamination, loss of clinical utility due to added time for cell expansion, and difficulty in obtaining healthy autologous cells from diseased donors.

TS-000242 — Researchers at Nationwide Children’s Hospital have developed a novel method for increasing the patency of biodegradable, synthetic vascular grafts. Administration or controlled release of one or more cytokines or chemokines was found to promote outward tissue remodeling of the vascular grafts and vascular neotissue formation. As a result, this method does not require cell seeding of the vascular graft, eliminating many problems associated with cell seeding such as contamination, loss of clinical utility due to added time for cell expansion, and difficulty in obtaining healthy autologous cells from diseased donors.