TS-005571 — This new urine‑based biomarker panel is specialized for the early, non‑invasive detection and monitoring of obstructive uropathy (OU), a condition that results from anatomical or functional urinary tract obstruction due to congenital causes. Despite the clinical importance of OU, there are currently no validated non-invasive biomarkers that can successfully detect early parenchymal injury, predict disease progression, or guide therapeutic intervention in obstructive nephropathy. These non-invasive biomarkers combine the urinary proteomics with single-cell transcriptomics from the urinary tract and kidney, allowing the identification and tracing of novel biomarkers to their cellular origins and the mapping of specific sites, leading to interventions to stabilize kidney and bladder function and prevent further deterioration and promote recovery.

TS-005568 — This new approach to using alpha-1 adrenoreceptor antagonists for fetal lower urinary tract obstruction (LUTO) therapeutically relaxes the obstructed fetal bladder outlet, thereby improving bladder emptying and preventing damage to fetal organs. LUTO impairs fetal bladder emptying, leading to megabladder, back‑pressure injury to the kidneys, and critically low amniotic fluid, which is essential for normal lung development. Currently, the only available treatments involve invasive surgeries that carry substantial risks and can fail or require repeat procedures. This is the first approach of its kind to describe the use of TAM or other α‑1 blockers as a targeted fetal therapy, making this method of use novel and potentially groundbreaking.

TS-000465 — Urinary Tract Obstruction (UTO) is one of the most common etiologies of prenatal hydronephrosis, a condition that can lead to permanent kidney damage if left untreated. A group of researchers at Nationwide Children’s Hospital have developed a new way to use specific uroepithelial proteins such as Antimicrobial Peptides (AMPs) as biomarkers of obstructive uropathy. This non-invasive procedure tremendously improves early detection of UTO, informs surgical management and enables postoperative monitoring of patients.