TS-000489 — Preterm birth is the leading cause of mortality and morbidity in young children with over a million deaths per year worldwide arising from Neonatal Complications (NC). Research scientists at Nationwide Children’s have developed a scoring grid that can be used for the early detection of NC in premature infants. Infant-specific risk knowledge which can be derived from this invention could help design individualized treatment for each preterm infant; thus, reduce hospitalization cost.

TS-000416 — Factor XIII deficiency is a genetic bleeding disorder characterized by deficiency of clotting factor XIII resulting in prolonged, uncontrolled bleeding episodes. Unfortunately, the currently available, clinically-approved Factor XIII activity assays are technically challenging. Researchers at Nationwide Children’s Hospital have developed a new method for the determination of blood coagulation factor XIII enzymatic activity in a conventional enzyme-linked immunosorbent assay (ELISA). This method enables direct quantification of factor XIII as opposed to currently available indirect methods of measurement. This proof-of-principle technology provides improved, sensitive and simplified procedure for factor XIII estimation.

TS-000165 — Determining the severity of urinary tract infections (UTIs) relies on patient reporting of symptoms, a difficult task when working with pediatric populations. Failure to identify severe cases of UTI can result in dangerous complications including renal scarring and urosepsis. Researchers at Nationwi…