TS-002169 — Existing models of Organ-on-a-Chip cost more to produce and have limited ability to functionally recapitulate human native tissues due to their limited incorporation of cell types. Researchers at Nationwide Children’s Hospital developed an improved model with their microfluidic Organ-on-a-chip fabrication based on 3D printing. This model optimizes and improves formulation of an extracellular matrix (ECM) that mimics the lamina propria (LP) to sustain the attachment and expansion of different cell types meaning this innovative model has cellular complexity that allows it to mimic human organs and replace animal models in various research settings.

TS-000610 — Hemorrhagic shock and resuscitation (HS/R)-induced injuries often result from trauma or severe blood loss and can quickly progress to organ failure. Researchers at Nationwide Children’s Hospital have developed a novel method for treating subjects at risk for HS/R by administering Heparin Binding-Epidermal Growth Factor (HB-EGF). Administration of HB-EGF protects intestinal epithelial and endothelial cells from HS/R-induced injury in a rat model. This novel method may have broad clinical availability for treating or preventing a range of intestinal injuries in pediatric and adult patients.

TS-000157 — Short bowel syndrome is a consequence of massive bowel resection performed in patients with various diseases. Transplantation of the small bowel may be beneficial, but results risk of graft rejection and complications. Investigators at Nationwide Children's and Nanofiber Solutions have developed…