Short bowel syndrome is a consequence of massive bowel resection performed in patients with various diseases. Transplantation of the small bowel may be beneficial, but results risk of graft rejection and complications. Investigators at Nationwide Children's and Nanofiber Solutions have developed a method of generating tissue engineered intestine (TEI). This process uses multiple cell types of a patient's own cells and multi-layered nanofiber scaffolds to generate full thickness, functional intestine that can be used to treat and manage short bowel syndrome.