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Neuregulin-1 as Protection from Respiratory Viral Infections
TS-002168 — Children have a higher chance of morbidity and mortality from respiratory viral infections. Severe respiratory viral infections like Respiratory Syncytial Virus (RSV) and Parainfluenza viruses can lead to the development of asthma in patients. Clinical researchers at Nationwide Children’s Hospital found that neuregulin-1 (Nrg-1) may be an effective and protective treatment for patients diagnosed with severe respiratory viral infections. Their successful models with mice showed that Nrg-1 may prevent post-viral airway disease and reduce mortality if further studied and applied to human patients in the future.
- College:
- Inventors: Grayson, Mitchell; Hussain, Rehan
- Licensing Officer: Murrah, Kyle
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Increasing the Yield of Respiratory Syncytial Virus Live Attenuated Vaccines
TS-000214 — Preventing RSV attachment protein cleavage in vaccine producing cells to increase yield.
A widespread economic problem of RSV vaccine candidates is their inefficient production. RSV vaccine candidates are produced in Vero, a cell line isolated from African green monkey kidney. Infectious disease experts at Nationwide Children’s Hospital have discovered RSV grown in Vero cells has …
- College:
- Inventors: Peeples, Mark; Corry, Jacqueline; Kwilas, Steve
- Licensing Officer: Zalucha, Ellen
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Enhanced Immunogenicity of a Modified Respiratory Syncytial Virus Vaccine with Mutations in One or Both Non-Structural Proteins
TS-000132 — Mutation of the RSV NS1/2 proteins to attenuate the virus and boost immunogenicity
Respiratory syncytial virus (RSV) is the leading cause of upper and lower respiratory tract infections in infants and young children, and the most common cause of bronchiolitis and pneumonia in children younger than 1-year of age. A vaccine does not exist in part because RSV non-structural protein g…
- College:
- Inventors: Peeples, Mark; Flano, Emilio; Mejias, Asuncion; Ramilo, Octavio; Teng, Michael Nan-hao (Mark)
- Licensing Officer: Zalucha, Ellen
