TS-000856 — Alveolar Rhabdomyosarcoma is a malignancy that forms in a muscle, stemming from a soft tissue and residing in the lungs. A team of researchers led by Dr. Benjamin Stanton have developed an initial characterization of PAX3-FOXO1 that is localized across the genome associated with this disease. PAX3-FOXO1 localizes to both repressed and active regions of the tumor genome and is initially targeted as a driver oncogene. Additionally, the immediate-early targets of localization encode metabolic genes and cell cycle genes. By understanding this rare tumor oncogene, caregivers will be able to identify target genes and implement FDA-approved therapies.