TS-005788 — This improved AAV vector–design strategy significantly reduces genome truncations caused by micro‑RNA–derived DNA hairpins during viral replication, introducing targeted point mutations within the DNA sequence encoding the micro‑RNA passenger strand. This innovation improves AAV batch quality, enhances efficacy and safety of micro‑RNA–based gene therapies, and reduces manufacturing cost.

TS-004703 — For AAVs that harbor gene knockdown machinery, this IP is a novel potency assay development for release testing that creates a HEK293T stable cell line to integrate two genetic components.

TS-004598 — This system may help improve the safety of AAV vector products by decreasing cross-packaged bacterial sequences, increasing correctly packaged AAV payloads and blunting ITR-driven transcription of cross-packaged material to avoid expressing potentially toxic bacterial sequences.