TS-005785 — This hands‑free dispensing device generates a refillable air reservoir to enable precise, controlled dispensing or withdrawal of small volumes of material by a single operator. This technology would have multiple applications in embryology where mouth pipettes are still quite common, perfusions of animal tissue with fixatives, dyes, etc.

TS-005780 — A novel mouse model engineered to recapitulate a human disease–associated variant in AIFM1, in which a valine at position 67 is replaced by a premature stop codon. This model provides a valuable in vivo platform for studying the mechanisms underlying AIFM1‑associated disease and for evaluating potential therapeutic strategies.

TS-005779 — These two novel mouse models investigate the role of Arf1 in human development and disease. One model carries a previously unreported missense variant (F51L) designed to recapitulate a human pathogenic mutation, while the second model contains a newly engineered two–base‑pair deletion in the same genomic region that results in a null allele.

TS-005776 — This novel mouse model is engineered to carry a human variant in ATP1A3, encoding the Na⁺/K⁺‑transporting ATPase alpha‑3 subunit. The model provides a unique in vivo platform for investigating the molecular and developmental mechanisms underlying ATP1A3‑associated neurodevelopmental disorders, serving as a valuable tool for disease‑mechanism discovery and proof‑of‑concept testing of potential therapeutic interventions.

TS-005771 — This new composition of matter contains two novel Kifap3 mouse alleles that provide new tools for studying the function of kinesin‑associated protein 3 and its relevance to human disease. Together, these mouse models establish a valuable platform for investigating Kifap3 biology, elucidating disease mechanisms, and supporting proof‑of‑concept studies for potential therapeutic interventions.

TS-005770 — This new composition of matter is a set of novel mouse alleles engineered to investigate the functional roles of Ift70a1 and Ift70a2, the two murine paralogs of the human IFT70A gene (also known as TTC30A), which arose through gene duplication in mice. This gives a robust platform for mechanistic discovery, validation of pathogenic variants, and proof‑of‑concept testing of potential therapeutic interventions targeting ciliary transport dysfunction.

TS-005672 — This new IP is a conditional Camsap1 allele meant to complement the published Camsap1 null model, which exhibits early embryonic lethality, and therefore allows researchers to bypass that limitation to study Camsap1 function in targeted cell types and developmental stages.

TS-004712 — Made with CRISPR-CAS9 genome editing technology, this mouse model tests if certain human variants cause craniofacial conditions.

TS-003708 — This IP seeks to treat omodysplasia by targeting the Wnt signaling pathway. Through the creation of mouse models with variants in the Frizzled2 gene—which mimic the human omodysplasia phenotype—preliminary data has shown that administering a small molecule intra-peritoneally to pregnant dams can rescue some skeletal defects in mouse embryos. By leveraging the known effects of Wnt agonists on skeletal development, the IP holds promise for addressing the skeletal defects associated with omodysplasia. As research progresses, the potential applications of this IP may extend beyond omodysplasia to other skeletal dysplasias and related conditions. The ability to target the Wnt signaling pathway opens doors to a range of therapeutic possibilities, offering hope to patients and clinicians seeking effective treatments for skeletal disorders. The IP embodies a significant advancement in the field of skeletal dysplasia research and holds promise for translating pre-clinical findings into potential therapeutic interventions. With continued development and collaboration, it has the potential to make a meaningful impact on the lives of individuals affected by omodysplasia and related conditions.