TS-005570 — A new way of using cardiac myosin activators can be used to treat underactive urinary bladder. Poor urinary bladder contraction, which affects millions of individuals, can be caused by many diseases and has no effective treatments. By repurposing existing cardiac myosin MYH7-activating drugs and designing new myosin-binding ligands, clinicians can improve detrusor smooth muscle (dSM) myosin MYH11 contraction. With this redesigned drug, clinicians can target smooth muscle myosin MYH11 to improve the contraction of visceral muscle.