TS-005787 — This custom DNA methylation microarray is designed to assess long‑term health risks and recovery potential associated with early‑life nutritional stress and starvation, based on the discovery of unique DNA methylation signatures that distinguish individuals who survived severe childhood starvation and achieved advanced age (70–80 years).

TS-005785 — This hands‑free dispensing device generates a refillable air reservoir to enable precise, controlled dispensing or withdrawal of small volumes of material by a single operator. This technology would have multiple applications in embryology where mouth pipettes are still quite common, perfusions of animal tissue with fixatives, dyes, etc.

TS-005784 — This novel, personalized hormone‑replacement therapy for anorexia nervosa (AN) simultaneously targets dysregulated ghrelin and leptin signaling using a transdermal skin‑patch delivery system. This represents a new device and treatment paradigm for AN, introducing both a previously undescribed hormone combination therapy and a precision‑medicine framework that tailors treatment based on epigenetic biomarkers, with strong translational potential supported by an existing, genomically characterized patient cohort.

TS-005780 — A novel mouse model engineered to recapitulate a human disease–associated variant in AIFM1, in which a valine at position 67 is replaced by a premature stop codon. This model provides a valuable in vivo platform for studying the mechanisms underlying AIFM1‑associated disease and for evaluating potential therapeutic strategies.

TS-005779 — These two novel mouse models investigate the role of Arf1 in human development and disease. One model carries a previously unreported missense variant (F51L) designed to recapitulate a human pathogenic mutation, while the second model contains a newly engineered two–base‑pair deletion in the same genomic region that results in a null allele.

TS-005776 — This novel mouse model is engineered to carry a human variant in ATP1A3, encoding the Na⁺/K⁺‑transporting ATPase alpha‑3 subunit. The model provides a unique in vivo platform for investigating the molecular and developmental mechanisms underlying ATP1A3‑associated neurodevelopmental disorders, serving as a valuable tool for disease‑mechanism discovery and proof‑of‑concept testing of potential therapeutic interventions.

TS-005771 — This new composition of matter contains two novel Kifap3 mouse alleles that provide new tools for studying the function of kinesin‑associated protein 3 and its relevance to human disease. Together, these mouse models establish a valuable platform for investigating Kifap3 biology, elucidating disease mechanisms, and supporting proof‑of‑concept studies for potential therapeutic interventions.

TS-005770 — This new composition of matter is a set of novel mouse alleles engineered to investigate the functional roles of Ift70a1 and Ift70a2, the two murine paralogs of the human IFT70A gene (also known as TTC30A), which arose through gene duplication in mice. This gives a robust platform for mechanistic discovery, validation of pathogenic variants, and proof‑of‑concept testing of potential therapeutic interventions targeting ciliary transport dysfunction.

TS-005768 — This novel genetic construct for allogeneic cellular therapies enables immune‑evasive persistence by selectively downregulating HLA class I molecules while preserving natural killer (NK) cell inhibition.

TS-005735 — This invention consists of a standardized protocol and supporting documentation developed for the 5000 Baby Project to govern the ethical collection, storage, management, and sharing of research data.