TS-000855 — To diagnose urinary tract infections (UTI), the current strategies use leukocyte esterase, a urine test to look for white blood cells and other signs of infection. which have limited accuracy. These inaccuracies put patients at risk for unneeded antibiotics or delayed treatments, that can allow for UTI progression. Studies have found that the protein levels in urine could differentiate positive and negative results of UTIs. This new testing strategy can improve diagnostics and subsequent patient care.

TS-000635 — Infectious peritonitis is a serious complication in patients undergoing chronic peritoneal dialysis (PD) leading to patient morbidity and mortality. Currently available, non-specific diagnostic criteria of peritonitis can lead to missed /over-diagnosis. Researchers at Nationwide Children’s Hospital have discovered more sensitive and specific biomarker for peritonitis in the PD population that entails measurement of antimicrobial peptide levels. This new process will aid practitioners in early, accurate diagnosis of acute peritonitis in patients undergoing PD.

TS-000489 — Preterm birth is the leading cause of mortality and morbidity in young children with over a million deaths per year worldwide arising from Neonatal Complications (NC). Research scientists at Nationwide Children’s have developed a scoring grid that can be used for the early detection of NC in premature infants. Infant-specific risk knowledge which can be derived from this invention could help design individualized treatment for each preterm infant; thus, reduce hospitalization cost.

TS-000465 — Urinary Tract Obstruction (UTO) is one of the most common etiologies of prenatal hydronephrosis, a condition that can lead to permanent kidney damage if left untreated. A group of researchers at Nationwide Children’s Hospital have developed a new way to use specific uroepithelial proteins such as Antimicrobial Peptides (AMPs) as biomarkers of obstructive uropathy. This non-invasive procedure tremendously improves early detection of UTO, informs surgical management and enables postoperative monitoring of patients.

TS-000416 — Factor XIII deficiency is a genetic bleeding disorder characterized by deficiency of clotting factor XIII resulting in prolonged, uncontrolled bleeding episodes. Unfortunately, the currently available, clinically-approved Factor XIII activity assays are technically challenging. Researchers at Nationwide Children’s Hospital have developed a new method for the determination of blood coagulation factor XIII enzymatic activity in a conventional enzyme-linked immunosorbent assay (ELISA). This method enables direct quantification of factor XIII as opposed to currently available indirect methods of measurement. This proof-of-principle technology provides improved, sensitive and simplified procedure for factor XIII estimation.

TS-000165 — Determining the severity of urinary tract infections (UTIs) relies on patient reporting of symptoms, a difficult task when working with pediatric populations. Failure to identify severe cases of UTI can result in dangerous complications including renal scarring and urosepsis. Researchers at Nationwi…