# of Displayed Technologies: 2 / 2

Applied Category Filter (Click To Remove): Biofilms


Methods for Anticipating Antibiotic Sensitivity in Bacteria Released from Biofilm Residence
TS-002176 — In order to effectively treat bacterial infections, a clear understanding of the bacterium’s antibiotic sensitivity is needed. Researchers at Nationwide Children’s Hospital’s Center for Microbial Pathogenesis created a new method to assist in prescribing antibiotics for infections caused by a biofilm to reduce the dosage and the length of antibiotic treatments.
Depending on the bacteria’s physiologic state the antibiotic sensitivity can be highly variable. Originally, bacteria were believed to exist in two physiologic states: planktonic and biofilm. However, the research team based their methods on two additional but transient physiologic states they…
  • College:
  • Inventors: Bakaletz, Lauren; Goodman, Steven
  • Licensing Officer: Murrah, Kyle

Small Molecules that Inhibit and Disperse Salmonella Biofilms in vitro and are Active in Combination with Ciprofloxacin in vivo
TS-001034 — Salmonella is often caused by contact with animals that carry bacteria, contaminated food, or water. It has been observed that children are commonly afflicted by salmonella, and typically treatment includes fluids, medical care, and sometimes pharmaceuticals. A team of researchers at Nationwide Children’s hospital have identified a lead compound that includes a biofilm with anti-salmonella characteristics and acts as an inhibitor. Use of this compound with the antibiotic ciprofloxacin improves the elimination of bacterial infection in at-risk organs such as the liver and spleen.
  • College:
  • Inventors: Gunn, John; Sandala, Jenna
  • Licensing Officer: Murrah, Kyle

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