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Utilizing Antisense Oligonucleotides to Modulate MDM2 Alternative Splicing
TS-000194 —
Investigators at Nationwide Children's Hospital have developed a novel splicing corrective treatment to modulate the splicing of p53-modifier Murine Double Minute 2 (MDM2) in cancer.
Murine Double Minute 2 (MDM2) is an E3 ubiquitin ligase and negative regulator of the tumor suppressor protein p53. Under normal conditions, MDM2 is constitutively spliced to generate a full-length protein and promotes the proteasome-mediated degradation of p53. However, under stress MDM2 undergoes …
- College:
- Inventors: Chandler, Dawn; Comiskey, Daniel
- Licensing Officer: Murrah, Kyle
