# of Displayed Technologies: 10 / 159


CPO-2 (continuous pulse oximeter) and Play on O-2 and C-3PO
TS-003440 — The Continuous Pulse Oximeter (CPO-2) is a conceptual wearable device designed for infants with Bronchopulmonary Dysplasia (BPD) and other patient populations requiring continuous oxygen monitoring. The National Institutes of Health estimates that 10,000-15,000 babies born in the United States develop BPD each year. Inspired by the concept of continuous glucose monitors (CGMs), the CPO-2 aims to offer a wireless, adhesive solution to address the challenges associated with traditional pulse oximeters. The intellectual property involves creating a device that is capable of reading oxygen saturations (spO2) without the need for a separate machine. Unlike current pulse oximeters that are minimally adhesive and connected to a machine via a cord, the CPO-2 would transmit information directly to a smartphone, eliminating the machine and cord, thereby reducing the risk of strangulation and skin breakdown issues. The adhesive component is expected to last for an extended period, potentially 7-10 days or more, reducing the need for frequent probe replacements. Potential applications include adoption by home care companies, which could provide the CPO-2 to families taking infants or children home on oxygen. The device could find utility across various age groups, offering a less cumbersome method for continuous oxygen saturation monitoring. RINCH has filed a provisional application (63/533,946) and the inventor continues to develop and refine this technology.
  • College:
  • Inventors: Ingram, Mindy
  • Licensing Officer: Zalucha, Ellen

Predictive Model of Sudden Cardiac Death in Anomalous Aortic Origin of Coronary Artery (AAOCA)
TS-003439 — The Predictive Model of Sudden Cardiac Death in Anomalous Aortic Origin of Coronary Artery (AAOCA) is a patient-specific computational modeling approach to predict ischemia risk in individuals with anomalous coronaries. Anomalous coronaries are variations or abnormalities in the anatomy of the coronary arteries. These anomalies can differ in presentation and severity, with some increasing the risk of heart problems, such as myocardial ischemia (reduced blood flow to the heart muscle), arrhythmias or sudden cardiac arrest. According to The Cleveland Clinic, up to 1% of the population has an anomalous coronary artery, and most cases are not dangerous. This predictive model utilizes morphological risk factors derived from advanced imaging data to offer a validated method for risk stratification, determining the need for surgery, selecting the type of surgery, assessing the effectiveness of surgery, and evaluating residual ischemia post-surgery. Because there are no effective risk stratification approaches for AAOCA individuals, predicting these life-threatening events is challenging. AAOCA is a significant cause of sudden death in children, and current understanding of the mechanisms leading to ischemia and sudden cardiac death (SCD) is limited. According to the Nora Eccles Harrison Cardiovascular Research and Training Institute, "SCD is one of the most significant causes of natural deaths globally. Annually, just over 300,000 US adult deaths are a result of sudden cardiac death. Roughly half of all cardiovascular disease deaths are from SCD." The proposed model addresses these gaps, potentially shifting the AAOCA field from uncertainty to clinical solutions. RINCH has filed a provisional application (63/502,524) for this technology. The inventors are planning additional refinement of the methodology and a clinical trial to validate the model in a prospective patient population. This technology is jointly owned with Georgia Institute of Technology.
  • College:
  • Inventors: Krishnamurthy, Rajesh
  • Licensing Officer: Zalucha, Ellen

Parent-Implemented Oral Nutrition, Eating and Esophageal Regulation (PIONEER) Products
TS-003438 — The Parent-Implemented Oral Nutrition, Eating and Esophageal Regulation (PIONEER) Products enhance development of oral-pharyngeal-esophageal motility in infants. This technology is a novel approach for training muscles in non-verbal patients, including neonates, infants, and individuals who have lost skills due to stroke, trauma, or developmental neuropathology. Unlike existing methods, these products stimulate muscles involved in esophageal peristalsis and airway protection without electrical stimulation. By engaging and pre-conditioning select muscles and nerves, the approach helps prevent developmental delays, cerebral palsy, and chronic eating and swallowing difficulties. Approximately half a million infants are admitted to NICUs in the USA annually, thus, the technology’s impact on infant feeding and airway issues could be significant. Potential applications range from diagnostic and therapeutic purposes to rehabilitative therapy for chronic tube-fed infants in Neonatal Intensive Care Units (NICUs) and post-discharge. RINCH has filed a patent application (PCT/US23/81696) and the inventor is continuing to conduct clinical investigations.
  • College:
  • Inventors: Jadcherla, Sudarshan
  • Licensing Officer: Zalucha, Ellen

VSV-based SARS-CoV-2 Vaccine Candidates and IgY Antibody as Prophylactic and Therapeutic Agents Against SARS-CoV-2 and Variants of Concern
TS-003437 — According to the CDC, roughly 1.1 million COVID-19 cases have been reported in the past year, and 81.4% of the U.S. population have received the updated booster dose. This therapeutic agent utilizes the vesicular stomatitis virus (VSV) vector to protect against SARS-CoV-2 and its variants. This innovative approach resulted in heightened immunogenicity of the vaccines compared to currently available options. Specifically, the utilization of the prefusion Spike protein, stabilized with six prolines (preS-6P), component in the vaccine formulation demonstrates superior efficacy in eliciting a robust immune response. Two distinguishing features of this vaccine platform are the proposed intranasal administration and the live attenuated virus design, both of which induce robust mucosal immunity. In addition to the vaccine platform, the inventors used the platform to develop specific IgY antibodies to SARS-CoV-2 that might be used as a prophylactic, therapeutic or diagnostic antibody. This technology holds significant promise in the development of effective vaccines to combat SARS-CoV-2 and its variants long-term. RINCH has filed a provisional application (63/452,870) and the inventors continue to evaluate the efficacy of the vaccine candidates in animal models. This technology is jointly owned with The Ohio State University.
  • College:
  • Inventors: Peeples, Mark; KC, Mahesh
  • Licensing Officer: Zalucha, Ellen

Prevention of Sudden Unexplained Infant Death Cell Phone App Idea Proposal
TS-003427 — The proposed cell phone application, currently in the pre-prototype stage, is designed to address the issue of Sudden Unexplained Infant Deaths (SUIDs). Tailored for parents, especially those with high-risk infants, the app integrates interactive features like safe sleep education, a daily checklist, and a secure photo submission mechanism for monitoring a baby’s safe sleep environment. There are devices on the market that parents can purchase, but they are not affordable or accessible. The proposed app would be a free alternative to the current expensive devices—with an incentivization feature for consistent household application following birthing center discharge. Beyond this, it serves as a tool to increase knowledge, instill safe sleep practices into caregivers’ daily routines, and directly shape safe behaviors. Aligned with Nationwide Children’s Hospital’s Safe Sleep Initiative taught in the Neonatal Intensive Care Unit (NICU), the app is not only educational, but also interactive, enhancing learning retainability. The device is marketable on a global scale, catering to every birthing center, NICU, and family worldwide. Emblazoned with the Nationwide Children’s logo, it sends a message that “Everyone Matters,” contributing to the publicization and awareness-building for Nationwide Children’s Hospital. In addition, the app aligns seamlessly with NCH’s inclusion and diversity initiatives by providing incentives, such as discount diapers and baby supplies, to all babies up to one year of age, irrespective of race, ethnicity, or gender identity. This comprehensive approach positions the app as not just a potential life-saving solution but also a valuable asset for companies interested in licensing products related to infant safety and well-being.
  • College:
  • Inventors: Smathers, Jodi
  • Licensing Officer: Mills, Joseph

Child Tracheostomy Task Trainer
TS-003412 — 4,800 pediatric patients undergo tracheostomies annually in the U.S., with multiple caregivers throughout their lives requiring training in the appropriate care. Nationwide Children’s Hospital simulation professionals have developed an innovative Pediatric Tracheostomy Task Trainer model. The manikin offers advanced features for more hands-on training, replicating real-life experiences, including applications such as CPR training. Existing commercially available task trainers have limitations, and the new model addresses these issues. The portable trainer caters to a broad audience, including healthcare professionals and students with tracheostomy tubes. Key skills associated with the device cover suctioning (both open and closed techniques), stoma care, tracheostomy tie changes, and rescue breathing through tracheostomy/face, depending on insertion availability. Notable improvements include advanced airway management and haptic feedback. The developed prototype has undergone successful training sessions for hospital staff and caregivers at Nationwide Children’s Hospital. Additionally, a provisional patent application has been filed. We are actively seeking commercial partners to license this technology in the training manikin market, projected to reach $2.60 billion by 2028 with an 11.2% compound annual growth rate.
  • College:
  • Inventors: Heater, Thomas; Coles, Mary
  • Licensing Officer: Mills, Joseph

Internal Hip Distraction
TS-002958 — Hip distraction, or arthrodiastasis, is a surgical option for end-stage diseases of the hip, such as Legg Calve Perthes disease, avascular necrosis, and end-stage osteoarthritis. The procedure improves mobility, decreases pain, and prevents further wear to avoid a total hip arthroplasty. However, the standard of care procedure requires an external device that uses large pins that are kept for 3-4 months which can be distressing for pediatric patients. NCH inventors have developed a completely internal hip-spanning device that allows for distraction and articulated hip motion. This device will likely reduce the problems associated with an external device such as infection, procedure failure, and psychosocial concerns.
  • College:
  • Inventors: Kadado, Allen
  • Licensing Officer: Zalucha, Ellen

Scoliosis 3D Model for Surgical Simulation
TS-002957 — Available 3D spine models do not optimize properties to simulate real-life bones, ligaments, tendons, viscoelasticity, or resistance that is present in a patient. Spine models are used by both surgeons and researchers for surgical planning, simulation, training, research and medical device development. By optimizing 3D printing materials, NCH inventors can produce patient-specific spine models that replicate the viscoelastic properties of the spine for a more accurate rendition. In addition to precise surgical planning, another benefit of utilizing viscoelastic accurate models is further medical device innovation to optimize surgical outcomes.
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  • Inventors: Kadado, Allen
  • Licensing Officer: Zalucha, Ellen

Targeting GSK3β in NK Cells for Enhanced Antitumor Activity.
TS-002302 — Acute myeloid leukemia (AML) causes myeloid cells to interfere with the production of healthy white blood cells, red blood cells and platelets; patients will experience fatigue, easy bruising, infections, etc. Due to expansion ex vivo with IL-15, AML patients and donors’ natural killer (NK) cells have an increase in glycogen synthase kinase 3 beta (GSK3β) from the loss of cytotoxicity and defective metabolism. Researchers at Nationwide Children’s Hospital targeted GSK3β in NK cells to promote antitumor activity by expanding NK cells with feeder cells expressing membrane-bound IL-21 without altering the GSK3β levels. They deleted GSK3β using the cas9/RNP and expanding paired-donor knock out and wild-type NK cells. When assessing transcriptional and functional alterations induced by the loss of GSK3β, GSK3β-KO cells demonstrated changes in gene expressions that suggested possible metabolic reprogramming and exhibited 150% higher spare respiratory capacity, a marker for metabolic fitness. By using mbIL21 expansion in the expansion of NK cells and GSK3β in these cells, the upregulation of GSK and drug inhibitors is prevented.
  • College:
  • Inventors: Lee, Dean; Naeimi Kararoudi, Meisam; Pereira, Marcelo
  • Licensing Officer: Corris, Andrew

Use of CD38 as the Integration Site for Enhanced Function of Gene-Modified Immune Effector Cells
TS-002301 — CD38 regulates the metabolism and the immunomodulation of tumor microenvironments, making it an essential component to anti-cancer therapies. Researchers at Nationwide Children’s Hospital developed a novel technology using CD38 as a new insertion site for NK and T cells. They generated CAR-NK and CAR-T cells by integrating the DNA encoding CAR in the CD38 locus to enhance anti-tumor activity and improve metabolic function of NK and T cells. Additionally, this can be used in combination with CD38 monoclonal antibodies without risking fratricide.
  • College:
  • Inventors: Lee, Dean; Naeimi Kararoudi, Meisam
  • Licensing Officer: Corris, Andrew

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