Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas of neural origin. The only known curative therapy is complete resection. Researchers at Nationwide Children’s Hospital have screened two novel compounds (Didesmethylrocaglamide and Rocaglamide) that are easy to synthesize owing to their compact structure and low molecular weight. These drugs show anti-tumor activity with no overt toxicity in murine model. This preclinical invention is a promising treatment for MPNST and other tumors.