Stability is a major challenge for live attenuated vaccine candidates because of the ability of viruses to revert to the wild-type phenotype. Virologists at Nationwide Children’s have shown that m6A-deficient viruses trigger high innate immune response while ensuring sufficient attenuation and enhanced genetic stability. As result, this method could make the rational design of live attenuated vaccine candidates for human respiratory syncytial virus (RSV), and other similar viruses.