Oncolytic viruses infect and replicate in tumor cells without harming normal tissue. Researchers at Nationwide Children’s Hospital have genetically engineered sophisticated ‘Herpes Simplex Viruses’ (HSVs) that express tumor associated antigens. These HSVs have elicited superior antitumor immune response against tumors in preclinical mouse models. These next generation HSVs are a valuable therapeutic option for controlling cancers.