Increasing Tissue Specific Gene Delivery by AAVrh74 Capsid Modification

Researchers at Nationwide Children's Hospital have identified modified capsid sequences of the Adeno-associated Virus rh74 (AAVrh74) native capsid that improve delivery of genes to specific target cells or overall global gene delivery. These include modifications that increase specific gene delivery to either the heart or muscle stem cells.

Patents

Patent # Title Country
ZL 201980018151.80 Increasing Tissue Specific Gene Delivery by Capsid Modification China
277270 Increasing Tissue Specific Gene Delivery by Capsid Modification Israel
7304878 Increasing Tissue Specific Gene Delivery by Capsid Modification Japan
2801217 Increasing Tissue Specific Gene Delivery by Capsid Modification Russia
11202008687X16/980,821 Increasing Tissue Specific Gene Delivery by Capsid ModificationIncreasing Tissue Specific Gene Delivery by Capsid Modification SingaporeUnited States of America
2019234918 Increasing Tissue Specific Gene Delivery by Capsid Modification Australia
3,092,353 Increasing Tissue Specific Gene Delivery by Capsid Modification Canada
1120200183547 Increasing Tissue Specific Gene Delivery by Capsid Modification Brazil
317905 Increasing Tissue Specific Gene Delivery by Capsid Modification Israel

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