Increasing Tissue Specific Gene Delivery by AAVrh74 Capsid Modification
Researchers at Nationwide Children's Hospital have identified modified capsid sequences of the Adeno-associated Virus rh74 (AAVrh74) native capsid that improve delivery of genes to specific target cells or overall global gene delivery. These include modifications that increase specific gene delivery to either the heart or muscle stem cells.
Patents
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Patent #
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Title
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Country
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7304878
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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Japan
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280121716/980,821
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Increasing Tissue Specific Gene Delivery by Capsid ModificationIncreasing Tissue Specific Gene Delivery by Capsid Modification
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RussiaUnited States of America
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2019234918
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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Australia
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3,092,353
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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Canada
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277270
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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Israel
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10-2020-7028750
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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Korea, South
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11202008687X
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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Singapore
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1120200183547
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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Brazil
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202410503648.4
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Increasing Tissue Specific Gene Delivery by Capsid Modification
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China
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