Non-invasive immunization tends to be more cost effective and has increased compliance compared to invasive vaccination methods making it ideal for both the developed and developing world. Researchers at Nationwide Children's have developed a method of immunizing against bacterial diseases of the respiratory tract, including ear infections, by applying a vaccine formulation to a patch and placing it on the skin behind the ear. Placement in this unique location is a non-invasive way of promoting an immune response to prevent or resolve infections.

Advantages

• Increased compliance
  • Noninvasive vaccine is painless, leading to increased patient acceptance
• Reduced costs
  • Simplified delivery devices and no requirement for trained medical personnel
• Treat infections
  • Resolve clinical signs of OM and reduce established biofilms
• Prevent infections
  • Induces both systemic and mucosal immunity

Stage of Development

Topical delivery of this chimeric vaccine has been proven effective in the chinchilla model of OM. Further investigation is ongoing to determine the molecular mechanisms that underlie the effectiveness of this approach as well as determine if effectiveness can be further improved by combining with other proprietary vaccine candidates.